| | Voucher Schemes | Liverpool | £3B |
| | Vouchers Scheme | Liverpool | £3B |
| | Main Management Contractors for Housing Development | Alfreton | £2B |
| | Courier and Specialist Movements | Liverpool | £2B |
| | Training Service to the Royal Navy and Royal Marines | Hampshire | £1B |
| | Major Project Partnering Framework - Large Capital Works | Belfast | £1B |
| | COVID Infection Survey (CIS)Services Related to COVID-19 - CIS Prime Provider | Gwent | £1B |
| | Prison Retail Service | London | £564M |
| | Wyke Community Sports Village (CSV) | Bradford | £444M |
| | ULEV and Hybrid Vehicles UK Wide Framework | Nottingham | £400M |
| | Post Office Banking Automation | London | £357M |
| | Cambridgeshire County Council Home and Community Support Services | Cambridge | £300M |
| | External and Internal Wall Insulation, Render Systems and Associated Works | Alfreton | £250M |
| | Trader Support Service | London | £241M |
| | Future Theory Test Service (FTTS) Test Centre Network (TCN) | Nottingham | £231M |
| | SARS-CoV-2 Antigen Rapid Qualitative Test Kits | London | £226M |
| | Development Partner Framework | Warrington | £200M |
| | Extra-Care Housing in Cornwall | Truro | £197M |
| | Vehicle Recovery and Disposal Managed Service | Guildford | £160M |
| | Regulated Homecare Services: For Providers in Somerset | Taunton | £155M |
| | Flexible Contracting Arrangement for Mental Health and Learning Disability Services | Shrewsbury | £155M |
| | SARS-CoV-2 Antigen Rapid Qualitative Test Kits | London | £152M |
| | Landsolve 2.0 — For Land Advisers/Brokers | Sheffield | £150M |
| | Management Consultancy Services | London | £145M |
| | LTE Vehicle Devices and Accessories for the Emergency Services Network (ESN) | London | £130M |
| | Trade Law Panel | Liverpool | £115M |
| | Appointment of a Development Partner for Phoenix 10 | Walsall | £114M |
| | Associated Services | Shrewsbury | £100M |
| | Contractor Framework | Wembley | £100M |
| | General Lab Equipment | London | £100M |
| | NMC OSCE Delivery Services | London | £100M |
| | Negative Pressure Wound Therapy | London | £98M |
| | Framework for Surfacing & Planing Works - Yorkshire Alliance | Huddersfield | £88M |
| | Framework for Surfacing Planing Works - Yorkshire Alliance | Huddersfield | £88M |
| | Care Home Provider for a Dual Registered Nursing and Residential Care Home | London | £78M |
| | Lake Lothing Third Crossing Build | Ipswich | £75M |
| | MHRA Regulatory Systems | London | £72M |
| | BHCC HP FH Housing Planned Maintenance and Improvement Programmes | Hove | £70M |
| | Home Fulfillment | Liverpool | £69M |
| | Lake Lothing Third Crossing Build | Ipswich | £68M |
| | Construction of an Ultra High Throughput Laboratory | London | £67M |
| | Coronavirus Ag Rapid Test Cassettes | London | £64M |
| | Housing Repairs and Maintenance | Ilford | £63M |
| | Serology - Rapid Antibody Test Kits | London | £62M |
| | Learning Disability Open for Providers in Somerset | Taunton | £60M |
| | Enteral Nutrition Products and Services Procurement the Leeds Health Economy | Leeds | £56M |
| | Audio Visual Technical Consultancy Commissioning | Liverpool | £50M |
| | Audio Visual Technical Consultancy & Commissioning | Liverpool | £50M |
| | Command and Staff Academic Provision | Swindon | £50M |
| | Estates Facilities Consultancy Dynamic Purchasing System | London | £50M |
| | Travel Management Services | West Malling | £50M |
| | Administration of the Civil Service Pensions Schemes | Liverpool | £45M |
| | National Traffic Information Service (NTIS) 2021+ | Bristol | £42M |
| | Large Capacity Aircraft Refueller and Small Capacity Aircraft Refueller Life Extension Project | Bristol | £41M |
| | Passive Fire Remedial Works | Croydon | £40M |
| | Replacement Product Spares, Repairs and Technical Support Including Post Design Services (PDS) and Non-Core PDS for… | Bristol | £40M |
| | Community Health Services | Bury | £38M |
| | Community Health Services for People in Bury | Bury | £38M |
| | High Potential Initial Teacher Training and Leadership Development Programme (2021 Cohort) | London | £37M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £36M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £34M |
| | Community Opportunity Services | Hertford | £32M |
| | National Ambulance Uniform and General Workwear | Sheffield | £32M |
| | Adult Skills Training Framework | Leeds | £30M |
| | Capital Works | Grays | £30M |
| | Met Office Delivery Partnerships Framework | Exeter | £30M |
| | Mental Health Accommodation Pathway Services | London | £30M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £28M |
| | Molecular Diagnostics DPS [3350705] | Londonderry | £28M |
| | Audiology Products | Cardiff | £27M |
| | Training in Agile and Project Management Skills — DPS for Skills Providers and Training Provision, Skills… | Chester | £27M |
| | Training in Occupational Health and Safety Skills — DPS for Skills Providers and Training Provision, Skills… | Chester | £27M |
| | Audit Services | Salford | £26M |
| | Variation / Further Extension of Contractual Term for the Major Project Leadership Academy (MPLA) | Liverpool | £25M |
| | Pharmacy Clean Room and the Related Consumables | Sheffield | £24M |
| | East Leeds Free School | Leeds | £24M |
| | Disposable Cubicle, Shower and Window Curtains | Sheffield | £24M |
| | Project Leadership Programme | London | £22M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £21M |
| | Acquisition, Design and Build Services for Telecoms Mast Base Station Sites for the Emergency Services Mobile… | London | £20M |
| | London and Quadrant Housing Trust — White Goods Framework 2021 | Stratford | £20M |
| | London and Quadrant Housing Trust - White Goods Framework 2021 - 2025 | London | £20M |
| | Marine and On-Shore Seismic Acquisition Services | Didcot | £20M |
| | Ready Meals | Leicester | £20M |
| | Strategic Partnering Initiative | Bristol | £20M |
| | Enabling Innovation Framework | Seascale | £19M |
| | Historical Railways Estate (HRE) - Examinations | Birmingham | £18M |
| | Spares Inclusive Upkeep (PAXMAN Diesel Engine Support ) | Bristol | £18M |
| | Supply, Services and Maintenance of Odour Control Units | Reading | £18M |
| | Personal Protective Equipment for Healthcare Workers for the Care of Patients With Suspected or Confirmed Novel… | London | £17M |
| | Framework for Block Opportunities in Care Homes | Huddersfield | £16M |
| | Rapid Access Beds | Huddersfield | £16M |
| | ABP Group Professional Services Framework GRP-FRA-21.008 | Hull | £15M |
| | Port of Lowestoft - Outer Harbour Upgrade | Lowestoft | £15M |
| | Supported Housing Accommodation and Housing Related Support Services | Lincoln | £15M |
| | UK Real Investment Management for Hampshire County Council Pension Fund | Hampshire | £14M |
| | XMNPROGQ1 | London | £13M |
| | Serology - Rapid Antibody Test Kits | London | £13M |
| | DHSC Laboratory Testing Services | London | £12M |
| | PIN - Early Learning and Childcare Framework | Newtown St Boswells | £12M |