| | Network Services 3 | Liverpool | £500B |
| | Digital Enablement and Transformation Solutions | Chester | £10B |
| | Network Services 3 | Liverpool | £5B |
| | Digital Specialists and Programmes | Liverpool | £4B |
| | Digital Specialists and Programmes (DSP) | Liverpool | £4B |
| | PIN - Modern Methods of Construction Supplier Engagement | Manchester | £4B |
| | NHS for Branded Medicines - National | Runcorn | £3B |
| | Health and Social Care Apps DPS | London | £3B |
| | Transport Technology and Associated Services | Liverpool | £2B |
| | Criminal Legal Aid Services From 1 October | London | £2B |
| | LB Enfield Affordable Housing Programme Framework | St Albans | £2B |
| | Tail Spend Solution | Liverpool | £1B |
| | Supply of Tyres | Telford | £942M |
| | NHS Supply Chain Future Operating Model - Logistics Services | London | £932M |
| | Fire Risk and Mitigation Works and Services | Manchester | £910M |
| | YORbuild2 West Area Contractors Framework Agreement | Leeds | £888M |
| | NOE CPC Minor Works, Trades and Associated Services DPS | Sheffield | £800M |
| | YORbuild2 East Area Contractors Framework Agreement | Beverley | £680M |
| | YORbuild2 South Area Contractors Framework Agreement | Rotherham | £352M |
| | Interim Combined Arms Virtual Simulation (Deployable) | Bristol | £344M |
| | Products for the Treatment of Bleeding Disorders Including Haemophilia B | Runcorn | £250M |
| | Passenger Transport 2021-2026 *For Quarterly Reporting Only* | Taunton | £230M |
| | Network Rail, Transpennine Route Upgrade (TRU), European Train Control System (ETCS) GRIP 4 -8 Framework | London | £228M |
| | Consultancy Services | Leicester | £200M |
| | YORbuild3 Minor Works Contractors East Area | Beverley | £180M |
| | YORbuild3 Minor Works Contractors West Area | Leeds | £180M |
| | Regulated Homecare Services: For Providers in Somerset | Taunton | £155M |
| | NHS for Branded Medicines - National | Runcorn | £149M |
| | YORbuild3 Minor Works Contractors South Area | Rotherham | £120M |
| | DPS for Asset Management Survey and Consultancy | London | £119M |
| | Prior Information Notice: NHS National Generic Pharmaceuticals - Lenalidomide | Runcorn | £116M |
| | Gigabit Infrastructure Subsidy Programme - Regional Supplier Cumbria | London | £109M |
| | YORbuild2 North Area Contractors Framework Agreement | Scarborough | £108M |
| | Integrated Healthcare Services to Thames Valley Prisons for NHS England and NHS Improvement South East | Oxford | £103M |
| | Integrated Community Equipment Services | Norwich | £100M |
| | LB Havering Complex Placements Framework - Round 17 | Romford | £100M |
| | Open Framework for Residential Care and Nursing Care of Older People Within the Borough of Barnsley… | South Yorkshire | £100M |
| | Residential and Nursing Home Framework Within the Borough of Barnsley | South Yorkshire | £100M |
| | Supported Living Services in Devon | Exeter | £100M |
| | Homes England - DPP3 - NEYTH Lot - West Lane, Ripon | Leeds | £90M |
| | NHS Education With Hull University Teaching Hospitals NHS Trust | Leeds | £85M |
| | NHS Education With Hull University Teaching Hospitals NHS Trust | Leeds | £85M |
| | Interventional Implantable Cardiac Devices and Accessories [3540294] | Belfast | £83M |
| | T-TG Bureau De Change Plus ATMs | Luton | £80M |
| | Information Solution Services (ISS) | Nottinghamshire | £70M |
| | Products for the Teratment of Bleeding Disorders | Runcorn | £70M |
| | YORbuild3 Minor Works Contractors North West Area | Scarborough | £68M |
| | Extension Sets and Lines | London | £60M |
| | Integrated Community Equipment Service (ECC & Partners) | Chelmsford | £60M |
| | Repairs and Maintenance | London | £60M |
| | Upgrade and Refurbishment of Hydrogas 3rd Generation Suspension Units | Bristol | £60M |
| | Aseptically Prepared Cytotoxic Medicines and Monoclonal Antibodies - East of England, London and South East Coast… | Runcorn | £52M |
| | YORbuild3 Minor Works Contractors North East Area | Scarborough | £52M |
| | Sexual Health and Reproductive Services | Liverpool | £51M |
| | Sexual Health and Reproductive Services | Liverpool | £51M |
| | Vulnerable Adults Support for Disabilities and Mental Health Services | Birmingham | £51M |
| | Health & Social Care Equipment and Associated Services | Wakefield | £50M |
| | SCC AM - Highways and Infrastructure Professional Services | Reigate | £50M |
| | Accommodation and Support for 16+ Older Looked After Young People and Care Leavers | Chichester | £45M |
| | Administration of FORS Concession | London | £45M |
| | Minor Engineering Works Framework 2022 | Exeter | £45M |
| | Recombinant Factor IX Products for the Treatment of Haemophilia B | Runcorn | £45M |
| | Children's Residential Care | Dorchester | £42M |
| | Mid and South Essex Non-Emergency Patient Transport Services (NEPTS) | Chelmsford | £41M |
| | Booking, Referral and Appointment Management Services Framework | Portsmouth | £40M |
| | RAL Minor Works | Swindon | £40M |
| | Spares, Parts, Consumables and Accessories for Land Rover Wolf | Telford | £40M |
| | NHS Education With East Lancashire Hospitals NHS Trust | Leeds | £37M |
| | NHS Education With East Lancashire Hospitals NHS Trust | Leeds | £37M |
| | NHS for the Suply of Aseptically Prepared Cytotoxic Medicines and Monoclonal Antibodies - North of England… | Runcorn | £36M |
| | NHS Education With Northumbria Healthcare NHS FT | Leeds | £36M |
| | NHS Education With Northumbria Healthcare NHS FT | Leeds | £36M |
| | West Marina Land and Development | Hastings | £35M |
| | West Marina Land Disposal and Development | Hastings | £35M |
| | MQS Port of Arrival – Category 3 Country and Territory Direct Arrivals at Heathrow Airport | London | £34M |
| | NHS Education Buckinghamshire Healthcare NHS Trust | Leeds | £34M |
| | NHS Education Buckinghamshire Healthcare NHS Trust | Leeds | £34M |
| | Oasis Community Learning ~ Catering Services | London | £34M |
| | NHS Education With Royal United Hospitals Bath NHS Foundation Trust | Leeds | £33M |
| | NHS Education With Royal United Hospitals Bath NHS Foundation Trust | Leeds | £33M |
| | Sub-Contractor Framework | Bilsthorpe | £32M |
| | Drum Handling System | Thurso | £31M |
| | NHS Education East Sussex Healthcare NHS Trust | Leeds | £31M |
| | NHS Education East Sussex Healthcare NHS Trust | Leeds | £31M |
| | Flexible Framework for Early Learning and Childcare Places | Paisley | £30M |
| | Food Sector Development Framework Agreement | Cardiff | £30M |
| | Sturry Link Road | Maidstone | £30M |
| | NHS Education With Blackpool Hospitals NHS Foundation Trust | Leeds | £28M |
| | NHS Education With Blackpool Hospitals NHS Foundation Trust | Leeds | £28M |
| | End to End Print Management Service | Liverpool | £28M |
| | NHS Education Sussex Partnership NHS Foundation Trust | Leeds | £28M |
| | NHS Education Sussex Partnership NHS Foundation Trust | Leeds | £28M |
| | Managed Service for Recovery, Storage and Disposal of Vehicles and Other Items | Glasgow | £27M |
| | Online Training in IT for Business Skills This Project Is Part Funded by the European Social… | Chester | £27M |
| | Growth Service for Businesses in Cambridgeshire & Peterborough | Ely | £27M |
| | Parking Enforcement Services | Hillingdon | £26M |
| | REACT Laboratory Testing Services | London | £26M |
| | Various Waste & Recycling Sacks | Hillingdon | £25M |
| | NHS Education With Alder Hey Children's NHS Foundation Trust | Leeds | £24M |
| | NHS Education With Alder Hey Children's NHS Foundation Trust | Leeds | £24M |